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Structural prediction of porcine sialoadhesin V-set Ig-like domain sheds some light on its role in porcine

Jie HOU,Rui LI,Hongfang MA,Songlin QIAO,Gaiping ZHANG

《农业科学与工程前沿(英文)》 2016年 第3卷 第1期   页码 65-71 doi: 10.15302/J-FASE-2016086

摘要: Porcine reproductive and respiratory syndrome (PRRS) is characterized by reproductive failures in sows and respiratory diseases in pigs of all ages. PRRS virus (PRRSV) is its causative agent and has caused huge economic losses in the swine industry. Porcine sialoadhesin (pSn) is a putative receptor of PRRSV. Previous studies have shown that a pSn V-set Ig-like domain is significant in PRRSV infection. However, its structural details are not fully known, hindering our deep understanding of PRRSV infection. In this study, we successfully cloned, expressed and purified the pSn V-set Ig-like domain in S2 cells. Then we tried to crystallize the target protein and predicted its structure. This will establish the foundation for the further structural study of pSn, deepen our understanding of the invasion mechanism of PRRSV, and support the structural information for the development of clinical drugs and vaccines against PRRSV.

关键词: PRRSV     porcine sialoadhesin     V-set Ig-like domain     Drosophila S2 cell     crystallization    

Maximum independent set in planning freight railway transportation

., Mladenovic NENAD, Rasskazova V. A.

《工程管理前沿(英文)》 2018年 第5卷 第4期   页码 499-506 doi: 10.15302/J-FEM-2018031

摘要:

This work is devoted to the problem of planning of freight railway transportation. We define a special conflict graph on the basis of a set of acceptable train routes. The investigation aims to solve the classical combinatorial optimization problem in relation to the maximum independent set of vertices in undirected graphs. The level representation of the graph and its tree are introduced. With use of these constructions, the lower and upper bounds for the number of vertices in the maximum independent set are obtained.

关键词: independent set     algorithm     planning of transportation     two-sided estimate    

能力集扩张的管理决策分析方法研究

王华亭, 冯俊文, 苗成林, 王健

《中国工程科学》 2008年 第10卷 第8期   页码 51-55

摘要:

能力集扩张(competence set expansion)是在决策过程中,决策者将已获得的能力集(competence set)拓展到解决问题所需能力集的过程

关键词: 能力集扩张     习惯领域     管理决策    

Study of engine performance, emission and combustion characteristics fueled with diesel-like fuel produced

V. Edwin Geo, Ankit Sonthalia, Fethi Aloui, Femilda Josephin J. S.

《环境科学与工程前沿(英文)》 2018年 第12卷 第4期 doi: 10.1007/s11783-018-1063-6

摘要:

To derive liquid fuel from waste engine oil and plastics thorough pyrolysis process

To make equal blend of waste engine oil and plastics with diesel fuel

To find the suitability of fuel from waste in diesel engine through performance, emission and combustion characteristics

关键词: Waste engine oil     Waste plastic oil     Diesel fuel     Pyrolysis     Compression ignition engine    

Time-domain and frequency-domain approaches to identification of bridge flutter derivatives

Zhengqing CHEN

《结构与土木工程前沿(英文)》 2009年 第3卷 第2期   页码 173-179 doi: 10.1007/s11709-009-0034-1

摘要: Flutter derivatives are essential for flutter analysis of long-span bridges, and they are generally identified from the vibration testing data of a sectional model suspended in a wind tunnel. Making use of the forced vibration testing data of three sectional models, namely, a thin-plate model, a nearly streamlined model, and a bluff-body model, a comparative study was made to identify the flutter derivatives of each model by using a time-domain method and a frequency-domain method. It was shown that all the flutter derivatives of the thin-plate model identified with the frequency-domain method and time-domain method, respectively, agree very well. Moreover, some of the flutter derivatives of each of the other two models identified with the two methods deviate to some extent. More precisely, the frequency-domain method usually results in smooth curves of the flutter derivatives. The formulation of time-domain method makes the identification results of flutter derivatives relatively sensitive to the signal phase lag between vibration state vector and aerodynamic forces and also prone to be disturbed by noise and nonlinearity.

关键词: long-span bridges     wind-induced vibration     flutter derivatives     forced vibration test     time-domain method     frequency-domain method    

Entity and relation extraction with rule-guided dictionary as domain knowledge

《工程管理前沿(英文)》   页码 610-622 doi: 10.1007/s42524-022-0226-0

摘要: Entity and relation extraction is an indispensable part of domain knowledge graph construction, which can serve relevant knowledge needs in a specific domain, such as providing support for product research, sales, risk control, and domain hotspot analysis. The existing entity and relation extraction methods that depend on pretrained models have shown promising performance on open datasets. However, the performance of these methods degrades when they face domain-specific datasets. Entity extraction models treat characters as basic semantic units while ignoring known character dependency in specific domains. Relation extraction is based on the hypothesis that the relations hidden in sentences are unified, thereby neglecting that relations may be diverse in different entity tuples. To address the problems above, this paper first introduced prior knowledge composed of domain dictionaries to enhance characters’ dependence. Second, domain rules were built to eliminate noise in entity relations and promote potential entity relation extraction. Finally, experiments were designed to verify the effectiveness of our proposed methods. Experimental results on two domains, including laser industry and unmanned ship, showed the superiority of our methods. The F1 value on laser industry entity, unmanned ship entity, laser industry relation, and unmanned ship relation datasets is improved by +1%, +6%, +2%, and +1%, respectively. In addition, the extraction accuracy of entity relation triplet reaches 83% and 76% on laser industry entity pair and unmanned ship entity pair datasets, respectively.

关键词: entity extraction     relation extraction     prior knowledge     domain rule    

Level set band method: A combination of density-based and level set methods for the topology optimization

Peng WEI, Wenwen WANG, Yang YANG, Michael Yu WANG

《机械工程前沿(英文)》 2020年 第15卷 第3期   页码 390-405 doi: 10.1007/s11465-020-0588-0

摘要: The level set method (LSM), which is transplanted from the computer graphics field, has been successfully introduced into the structural topology optimization field for about two decades, but it still has not been widely applied to practical engineering problems as density-based methods do. One of the reasons is that it acts as a boundary evolution algorithm, which is not as flexible as density-based methods at controlling topology changes. In this study, a level set band method is proposed to overcome this drawback in handling topology changes in the level set framework. This scheme is proposed to improve the continuity of objective and constraint functions by incorporating one parameter, namely, level set band, to seamlessly combine LSM and density-based method to utilize their advantages. The proposed method demonstrates a flexible topology change by applying a certain size of the level set band and can converge to a clear boundary representation methodology. The method is easy to implement for improving existing LSMs and does not require the introduction of penalization or filtering factors that are prone to numerical issues. Several 2D and 3D numerical examples of compliance minimization problems are studied to illustrate the effects of the proposed method.

关键词: level set method     topology optimization     density-based method     level set band    

Damage identification in connections of moment frames using time domain responses and an optimization

《结构与土木工程前沿(英文)》 2021年 第15卷 第4期   页码 851-866 doi: 10.1007/s11709-021-0739-3

摘要: Damage is defined as changes to the material and/or geometric properties of a structural system, comprising changes to the boundary conditions and system connectivity, adversely affecting the system’s performance. Inspecting the elements of structures, particularly critical components, is vital to evaluate the structural lifespan and safety. In this study, an optimization-based method for joint damage identification of moment frames using the time-domain responses is introduced. The beam-to-column connection in a metallic moment frame structure is modeled by a zero-length rotational spring at both ends of the beam element. For each connection, an end-fixity factor is specified, which changes between 0 and 1. Then, the problem of joint damage identification is converted to a standard optimization problem. An objective function is defined using the nodal point accelerations extracted from the damaged structure and an analytical model of the structure in which the nodal accelerations are obtained using the Newmark procedure. The optimization problem is solved by an improved differential evolution algorithm (IDEA) for identifying the location and severity of the damage. To assess the capability of the proposed method, two numerical examples via different damage scenarios are considered. Then, a comparison between the proposed method and the existing damage identification method is provided. The outcomes reveal the high efficiency of the proposed method for finding the severity and location of joint damage considering noise effects.

关键词: damage identification     beam-to-column connection     time-domain response     optimization    

机器人任务规划:基于PDDL和ASP的任务规划系统实验比较研究 Special Feature on Intelligent Robats

Yu-qian JIANG, Shi-qi ZHANG, Piyush KHANDELWAL, Peter STONE

《信息与电子工程前沿(英文)》 2019年 第20卷 第3期   页码 363-373 doi: 10.1631/FITEE.1800514

摘要: 本文比较了目前最先进的基于规划领域定义语言(planning domain description language, PDDL)和回答集程序(answer set programming, ASP)规划器的性能

关键词: 任务规划;机器人;规划领域定义语言(PDDL);回答集程序(ASP)    

Operating mechanism and set pair analysis model of a sustainable water resources system

Chaoyang DU,Jingjie YU,Huaping ZHONG,Dandan WANG

《环境科学与工程前沿(英文)》 2015年 第9卷 第2期   页码 288-297 doi: 10.1007/s11783-014-0642-4

摘要: There is no alternative to the world’s water resources, and their increasing scarcity is making it difficult to meet the world population’s water needs. This paper presents a sustainable water resources system (SWRS) and analyzes the operating mechanism that makes it possible to evaluate the status of such a system. A SWRS can be described as a complex coupling system that integrates water resources, social, economic and ecological systems into a whole. The SWRS’s operating mechanism is composed of dynamic, resistance and coordination components, and it interacts with and controls the system’s evolution process. The study introduces a new approach, set pair analysis theory, to measure the state of a SWRS, and an evaluation index system is established using the subsystems and operating mechanism of a SWRS. The evaluation index system is separated into three levels (goal level, criteria level and index level) and divides the index standard into five grades. An evaluation model of the SWRS based on set pair analysis theory is constructed, and an example of SWRS evaluation in Shanghai is presented. The connection degrees of the index in the three levels are calculated, and the connection degree of the goal index is calculated to be 0.342, which classifies the city’s SWRS condition as grade 2. The sustainable use of water resources in the region is determined to be at a relatively adequate level that meets the requirements of sustainable development.

关键词: sustainable water resources system     operating mechanism     set pair analysis model     Shanghai    

Distinct immune escape and microenvironment between RG-like and pri-OPC-like glioma revealed by single-cell

《医学前沿(英文)》 doi: 10.1007/s11684-023-1017-7

摘要: The association of neurogenesis and gliogenesis with glioma remains unclear. By conducting single-cell RNA-seq analyses on 26 gliomas, we reported their classification into primitive oligodendrocyte precursor cell (pri-OPC)-like and radial glia (RG)-like tumors and validated it in a public cohort and TCGA glioma. The RG-like tumors exhibited wild-type isocitrate dehydrogenase and tended to carry EGFR mutations, and the pri-OPC-like ones were prone to carrying TP53 mutations. Tumor subclones only in pri-OPC-like tumors showed substantially down-regulated MHC-I genes, suggesting their distinct immune evasion programs. Furthermore, the two subgroups appeared to extensively modulate glioma-infiltrating lymphocytes in distinct manners. Some specific genes not expressed in normal immune cells were found in glioma-infiltrating lymphocytes. For example, glial/glioma stem cell markers OLIG1/PTPRZ1 and B cell-specific receptors IGLC2/IGKC were expressed in pri-OPC-like and RG-like glioma-infiltrating lymphocytes, respectively. Their expression was positively correlated with those of immune checkpoint genes (e.g., LGALS3) and poor survivals as validated by the increased expression of LGALS3 upon IGKC overexpression in Jurkat cells. This finding indicated a potential inhibitory role in tumor-infiltrating lymphocytes and could provide a new way of cancer immune evasion.

关键词: single-cell RNA-seq     glioma     radial glia     primitive oligodendrocyte precursor cell     immune escape    

Autoimmunity in acute ischemic stroke and the role of blood—brain barrier: the dark side or the light one?

Nikolay V. Tsygan, Alexandr P. Trashkov, Igor V. Litvinenko, Viktoriya A. Yakovleva, Alexandr V.

《医学前沿(英文)》 2019年 第13卷 第4期   页码 420-426 doi: 10.1007/s11684-019-0688-6

摘要: This article presents a synopsis of the current data on the mechanisms of blood—brain barrier (BBB) alteration and autoimmune response in acute ischemic stroke. Most researchers confirm the relationship between the severity of immunobiochemical changes and clinical outcome of acute ischemic stroke. Ischemic stroke is accompanied by aseptic inflammation, which alters the brain tissue and exposes the co-stimulatory molecules of the immune system and the neuronal antigens. To date, BBB is not considered the border between the immune system and central nervous system, and the local immune subsystems are found within and behind the BBB. BBB disruption contributes to the leakage of brain autoantigens and induction of secondary autoimmune response to neuronal antigens and long-term inflammation. Glymphatic system function is altered and jeopardized both in hemorrhagic and ischemic stroke types. The receptors of innate immunity (toll-like receptor-2 and toll-like receptor-4) are also involved in acute ischemia—reperfusion injury. Immune response is related to the key processes of blood clotting and fibrinolysis. At the same time, the stroke-induced immune activation may promote reparation phenomena in the brain. Subsequent research on the reduction of the acute ischemic brain injury through the target regulation of the immune response is promising.

关键词: stroke     blood–brain barrier     autoimmunity     innate immunity     inflammation     cell death    

Terahertz time-domain spectroscopy of high-pressure flames

Jason BASSI, Mark STRINGER, Bob MILES, Yang ZHANG

《能源前沿(英文)》 2009年 第3卷 第2期   页码 123-133 doi: 10.1007/s11708-009-0033-x

摘要: Laser spectroscopy in the visible and near infrared is widely used as a diagnostic tool for combustion devices, but this approach is difficult at high pressures within a sooty flame itself. High soot concentrations render flames opaque to visible light, but they remain transparent to far-infrared or terahertz (THz) radiation. The first far-infrared absorption spectra, to the best of our knowledge, of sooty, non-premixed, ethylene high-pressure flames covering the region of 0.2-2.5 THz is presented. A specially designed high-pressure burner which is optically accessible to THz radiation has been built allowing flame transmission measurements up to pressures of 1.6 MPa. Calculations of the theoretical combustion species absorption spectra in the 0.2-3 THz range have shown that almost all the observable features arise from H O. A few OH (1.84 and 2.51 THz), CH (2.58 THz), and NH (1.77 and 2.95 THz) absorption lines are also observable in principle. A large number of H O absorption lines are observed in the ground vibrational in a laminar non-premixed, sooty flame (ethylene) at pressures up to 1.6 MPa.

关键词: terahertz time-domain spectroscopy     high-pressure flames     H2O absorption lines    

Self-sacrificial templating synthesis of flower-like nickel phyllosilicates and its application as high-performance

《化学科学与工程前沿(英文)》 2022年 第16卷 第4期   页码 484-497 doi: 10.1007/s11705-021-2074-6

摘要: The nanocomposites of flower-like nickel phyllosilicate particles incorporated into epoxy resin were fabricated via an in-situ mixing process. The flower-like nickel phyllosilicate particles were firstly synthesized using a mild self-sacrificial templating method, and the morphology and lamellar structure were examined carefully. Several properties of mechanical, thermal and tribological responses of epoxy nanocomposites were performed. It was demonstrated that adequate flower-like nickel phyllosilicate particles dispersed well in the matrix, and the nanocomposites displayed enhanced tensile strength and elastic modulus but decreased elongation at break as expected. In addition, friction coefficient and wear rate were increased first and then decreased along with the particle content, and showed the lowest values at a mass fraction of 5%. Nevertheless, the incorporated flower-like nickel phyllosilicate particles resulted in the continuously increasing thermal stability of epoxy resin (EP) nanocomposites. This study revealed the giant potential of flower-like particles in preparing high-quality EP nanocomposites.

关键词: nickel phyllosilicate     flow-like structure     mechanical property     thermal stability     tribological performance    

framework for underground structures in layered ground under inclined P-SV waves using stiffness matrix and domain

《结构与土木工程前沿(英文)》 2023年 第17卷 第1期   页码 10-24 doi: 10.1007/s11709-022-0904-3

摘要: A numerical framework was proposed for the seismic analysis of underground structures in layered ground under inclined P-SV waves. The free-field responses are first obtained using the stiffness matrix method based on plane-wave assumptions. Then, the domain reduction method was employed to reproduce the wavefield in the numerical model of the soil–structure system. The proposed numerical framework was verified by providing comparisons with analytical solutions for cases involving free-field responses of homogeneous ground, layered ground, and pressure-dependent heterogeneous ground, as well as for an example of a soil–structure interaction simulation. Compared with the viscous and viscous-spring boundary methods adopted in previous studies, the proposed framework exhibits the advantage of incorporating oblique incident waves in a nonlinear heterogeneous ground. Numerical results show that SV-waves are more destructive to underground structures than P-waves, and the responses of underground structures are significantly affected by the incident angles.

关键词: underground structures     seismic response     stiffness matrix method     domain reduction method     P-SV waves    

标题 作者 时间 类型 操作

Structural prediction of porcine sialoadhesin V-set Ig-like domain sheds some light on its role in porcine

Jie HOU,Rui LI,Hongfang MA,Songlin QIAO,Gaiping ZHANG

期刊论文

Maximum independent set in planning freight railway transportation

., Mladenovic NENAD, Rasskazova V. A.

期刊论文

能力集扩张的管理决策分析方法研究

王华亭, 冯俊文, 苗成林, 王健

期刊论文

Study of engine performance, emission and combustion characteristics fueled with diesel-like fuel produced

V. Edwin Geo, Ankit Sonthalia, Fethi Aloui, Femilda Josephin J. S.

期刊论文

Time-domain and frequency-domain approaches to identification of bridge flutter derivatives

Zhengqing CHEN

期刊论文

Entity and relation extraction with rule-guided dictionary as domain knowledge

期刊论文

Level set band method: A combination of density-based and level set methods for the topology optimization

Peng WEI, Wenwen WANG, Yang YANG, Michael Yu WANG

期刊论文

Damage identification in connections of moment frames using time domain responses and an optimization

期刊论文

机器人任务规划:基于PDDL和ASP的任务规划系统实验比较研究

Yu-qian JIANG, Shi-qi ZHANG, Piyush KHANDELWAL, Peter STONE

期刊论文

Operating mechanism and set pair analysis model of a sustainable water resources system

Chaoyang DU,Jingjie YU,Huaping ZHONG,Dandan WANG

期刊论文

Distinct immune escape and microenvironment between RG-like and pri-OPC-like glioma revealed by single-cell

期刊论文

Autoimmunity in acute ischemic stroke and the role of blood—brain barrier: the dark side or the light one?

Nikolay V. Tsygan, Alexandr P. Trashkov, Igor V. Litvinenko, Viktoriya A. Yakovleva, Alexandr V.

期刊论文

Terahertz time-domain spectroscopy of high-pressure flames

Jason BASSI, Mark STRINGER, Bob MILES, Yang ZHANG

期刊论文

Self-sacrificial templating synthesis of flower-like nickel phyllosilicates and its application as high-performance

期刊论文

framework for underground structures in layered ground under inclined P-SV waves using stiffness matrix and domain

期刊论文